Like most of the teachers in Jerome Horwitz Elementary School, Ms. Anthrope is not very nice. She is the school secretary. Her name is a pun on the word 'misanthrope' Captain Underpants and the Perilous Plot of Professor Poopypants, when she wears a crop top on a school field trip. Her usual way of hiding her belly button is by covering it with clothing, which has little effect, since her belly button sticks out so much that it is very visible even underneath the clothing. She is probably so hateful toward George and Harold for the sole purpose that, in every comic book they made with her in it, they purposely drew a bulging outie belly button to further humiliate her. She is currently in jail due to the events in book eleven.
Captain Underpants and the Attack of the Talking Toilets
Ms. Anthrope along with Mr. Krupp, Mr. Meaner, and Miss Ribble bully George and Harold because they where suspended, she is later along with nearly all the other staff, eaten by one of the talking toilets! But when Captain Underpants, George and Harold defeat the talking toilets and everything restored they are convinced it was a dream. She is last seen in the detention room writing sentences along with the other teachers who where mean to George and Harold after they where made principals for the day, but after realizing that in order to pay for the big day of fun George and Harold had sold Mr. Krupp's antique chair and desk, Mr. Krupp is furious, George and Harold attempt to make an escape but Ms. Anthrope snaps her fingers at them causing Mr. Krupp to turn into captain Underpants.
Captain Underpants and the Invasion of the Incredibly Naughty Cafeteria Ladies From Outer Space
Ms. Anthrope, like pretty much all of the school was turned into a zombie nerd due to the food that the evil alien lunch ladies served everyone, when George and Harold are trying to prove to Mr. Krupp that their are aliens invading the school and they have turned everyone into zombie nerds they use Ms. Anthrope as an example but although she looked like a zombie nerd Mr. Krupp wasn't persuaded that easily but when she takes a bite out of Mr. Krupp's desk, it is then when he starts to believe them.
Captain Underpants and the Perilous Plot of Professor Poopypants
George and Harold are banned from the school field trip to Piqua Pizza Palace, instead they had to clean the staff room, when the teachers and students got back from the field trip, her along with Mr. Krupp, Mr. Meaner, Ms. Ribble, Miss Calculator, and another teacher bully George and Harold, when they get bored of bullying them they head back up to the staff room, but they didn't count on the fact that George and Harold had set the place up with pranks!
Captain Underpants and the Wrath of the Wicked Wedgie Woman
When Ms. Ribble sent George and Harold to Mr. Krupp's office, Ms. Anthrope told them that Mr. Krupp was on the phone. She then made the boys copy off the Friday Memo while she went to lunch. George and Harold, however, re-did the memo to fit their own silly ideas, and passed the Memos out, making the following week very strange. She appears at Ms. Ribble's Retirement Party, where, after Mr. Krupp hands over Harold's card that makes Ms. Ribble think Mr. Krupp has proposed to her, she tells them that she will arrange everything, and although she wasn't seen at the wedding, she most likely showed up due to her enthusiasm and most likely was splashed with food in Ms. Ribble's fit of rage.
Captain Underpants and the Big, Bad Battle of the Bionic Booger Boy Part 1
After Melvin Sneedly (the Booger Boy) goes on a rampage, Ms. Anthrope is captured by him. Captain Underpants rescues her, but she becomes a plot device by kissing Captain Underpants with a lot of slobber. This works the same as pouring water on his head, so Captain Underpants goes back to being Mr. Krupp, and is eaten up by the booger boy.
Captain Underpants and the Big, Bad Battle of the Bionic Booger Boy Part 2
When Mr. Krupp was in Melvin's body, he demanded a cup of coffee from Ms. Anthrope, and assuming it was Melvin Sneedly talking to her she refused and was furious at him. She is later seen among the many people of whom Mr. Krupp annoyed while in Melvin's body chasing the real Melvin.
Captain Underpants and the Tyrannical Retaliation of the Turbo Toilet 2000
Ms. Anthrope is first seen congratulating Mr. Krupp for punishing George and Harold for not coming to school on test day, Ms. Anthrope is also the first of the teachers to be convinced that she is dreaming and therefore she can do whatever she wants, so she strips off down to her bra and underwear and started causing mayhem, soon Mr. Meaner, Miss Labler, and Ms. Ribble all joined in also convinced that they are dreaming, and it didn't stop until every teacher in the school was going mad, soon the police arrive and arrest all the teachers (Ms. Anthrope included) and take them to jail.
Depiction in the Film
The First Look at Edith Anthrope in The Film